Nature

Non-Inferiority Trials in Three-Arm Clinical Studies

Non-inferiority trials have become an essential instrument in clinical research, particularly when the goal is to demonstrate that an experimental treatment is not unacceptably worse than an ...
BMJ

Economic evaluations in ‘non-inferiority’ trials: can costs guide decisions between surgical and non-surgical interventions?

Correspondence to Professor Steven M McPhail, Australian Centre for Health Services Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia; steven.mcphail{at}qut.edu.au ...
Nasdaq

Outlook Therapeutics Reports Positive 12-Week Results for ONS-5010 in Wet AMD Non-Inferiority Trial and Plans BLA Resubmission for 2025

ONS-5010 shows non-inferiority to Lucentis at 12 weeks; BLA resubmission planned for Q1 2025, with $20.4M in proceeds expected. ONS-5010 demonstrated non-inferiority to ranibizumab at week 12, ...
ascopubs.org

ROCC/GOG-3043: A randomized non-inferiority trial of robotic versus open radical hysterectomy for early-stage cervical cancer.

Randomized controlled trial of the efficacy of lymph node dissection on stage IIICr of cervical cancer (CQGOG0103). Background: Minimally invasive surgery (MIS) is associated with improved ...