A Johns Hopkins-led study reports that severe obesity in people with heart failure with preserved ejection fraction (HFpEF) is linked to weakened contraction of heart muscle cells, but this defect may ...

According to the research, the protein seems to sense stress on the muscle cells and adjusts sarcomere shortening—and consequently, muscle contraction—based on how hard the heart needs to work. If ...

In a new research report, a team of scientists led by Johns Hopkins Medicine say people with severe obesity and a common type of heart failure experience weakened heart muscles, and that losing weight ...